[BB creatine kinase isoenzyme activity in the blood serum of patients with senile dementia, Alzheimer's disease and schizophrenia].

Abstract

Total creatine kinase (CPK) activity and the activity of brain-type creatine kinase (CPK BB) was determined in the blood serum of schizophrenic patients, senile dementia and Alzheimer disease patients and mentally sane individuals by means of bioluminescence assay. The increased activity of total CPK in the serum of schizophrenics and a 2-fold increase of CPK BB activity in the serum of patients with these mental diseases was demonstrated. The findings suggest the presence of destructive processes not only in demented brains but also in the schizophrenic brains.

• Authors: M V Aksenova, G Sh Burbaeva
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 89 Issue 9 Pg. 113-6 ( 1989) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Aktivnos't BB-kreatinfosfokinazy v syvorotke krovi bo'lnykh seni'lnoĭ dementsieĭ, bolez'niu A'ltsgeĭmera i shizofrenieĭ.
• PMID: 2609817 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Isoenzymes
• Creatine Kinase

Topics

• Adult
• Age Factors
• Aged
• Alzheimer Disease (enzymology)
• Creatine Kinase (blood)
• Dementia (enzymology)
• Female
• Humans
• Isoenzymes
• Male
• Middle Aged
• Schizophrenia (enzymology)
• Sex Factors