Aim. (1) The aim of the clinical study revolves around the accurate diagnosis, proper case selection, and the management of acute irreversible
pulpitis in permanent molars with closed apices using conservative and economical treatment modalities like vital
pulpotomies with regenerative approaches over conventional root canal procedures. (2) To evaluate the use of autologous substances such as platelet concentrates and
calcium silicate based materials in promoting the healing and regeneration of the inflamed pulp. Summary. Vital
pulpotomy was performed on 5 carious involved, permanent molars diagnosed with acute irreversible
pulpitis in 17- to 22-year-old patients. Taking into consideration the patient's age and the condition of the underlying pulp tissue, PRF
pulpotomy was planned in view of preserving the vitality of the intact radicular pulps. Regenerative procedures with second generation blood matrices were chosen to encourage the recovery of the inflamed pulps. The systematic follow-up examinations performed at 3, 6, 9, 12, 18, 22, and 24 months revealed a successful clinical and radiological outcome. Within the limits of the present clinical study and correlating the success across the treated clinical cases, we safely conclude the potential scope of regenerative
pulpotomy approaches in acute irreversible
pulpitis in adult permanent teeth.