Frequency of Intracranial Aneurysms Determined by Magnetic Resonance Angiography in Children (Mean Age 16) Having Operative or Endovascular Treatment of Coarctation of the Aorta (Mean Age 3).
|
| Abstract |
Coarctation of the aorta (CofA) has been associated with an increased risk of intracranial aneurysm (IA). This magnetic resonance angiography (MRA) study investigates the prevalence of IAs in 80 children treated in early life for CofA. MRA was performed at mean age of 15.7 ± 7.1 years, and surgical or endovascular treatment for CofA occurred at a mean age of 2.6 ± 4.4 years. No IA was found. In contrast with earlier findings in adult patients with late treatment for CofA, this first systematic study of very early treated patients for CofA failed to confirm the association between CofA and IAs. Our results call the abnormal developmental relation between CofA and IAs into question and suggest that modifiable risk factors like hypertension may be responsible for IA development in patients with CofA with adult diagnosis and treatment. In conclusion, our data suggest that early treatment of CofA can reduce the formation of IAs in children so as to make MRA screening less valuable in this young population.
|
|---|---|
| Authors | Andrea Donti, Luca Spinardi, Maurizio Brighenti, Luca Faccioli, Chiara Leoni, Marianna Fabi, Marco P Trossello, Gaetano D Gargiulo, Marco Bonvicini |
| Journal | The American journal of cardiology (Am J Cardiol) Vol. 116 Issue 4 Pg. 630-3 (Aug 15 2015) ISSN: 1879-1913 [Electronic] United States |
| PMID | 26096998 (Publication Type: Journal Article) |
| Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!