HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease.

Abstract
Aspirin is widely used in the primary and secondary prevention of cardiovascular diseases. The aim of our study was to compare between two established methods of aspirin response, urinary 11-dehydrothromboxane B2 (11dhTXB2) and platelet Light Transmission Aggregometry (LTA) assays in elderly Chinese patients with coronary artery disease (CAD), and to investigate the clinical significance of both methods in predicting cardiovascular events. Urinary 11dhTxB2 assay and arachidonic acid-induced (AA, 0.5mg/ml) platelet aggregation by Light Transmission Aggregometry (LTAAA) assay were measured to evaluate aspirin responses. High-on aspirin platelet reactivity (HAPR) was defined as urinary 11dhTxB2>1500pg/mg or AA-induced platelet aggregation≥15.22%-the upper quartile of our enrolled population. The two tests showed a poor correlation for aspirin inhibition (r=0.063) and a poor agreement in classifying HAPR (kappa=0.053). With a mean follow-up time of 12months, cardiovascular events occurred more frequently in HAPR patients who were diagnosed by LTA assay as compared with no-HAPR patients (22.5% versus 10.6%, P=0.039, OR=2.45, 95% CI=1.06-5.63). However, the HAPR status, as determined by urinary 11dTXB2 measurement, did not show a significant correlation with outcomes.
AuthorsTengfei Liu, Jingwei Zhang, Xiahuan Chen, Xueru Feng, Sidney W Fu, Timothy A McCaffrey, Meilin Liu
JournalGene (Gene) Vol. 571 Issue 1 Pg. 23-7 (Oct 15 2015) ISSN: 1879-0038 [Electronic] Netherlands
PMID26095809 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier B.V. All rights reserved.
Chemical References
  • Platelet Aggregation Inhibitors
  • Arachidonic Acid
  • Thromboxane B2
  • 11-dehydro-thromboxane B2
  • Aspirin
Topics
  • Aged
  • Aged, 80 and over
  • Arachidonic Acid (pharmacology)
  • Aspirin (therapeutic use)
  • Blood Platelets (drug effects, metabolism)
  • Coronary Artery Disease (blood, drug therapy, urine)
  • Female
  • Humans
  • Male
  • Platelet Aggregation (drug effects)
  • Platelet Aggregation Inhibitors (therapeutic use)
  • Platelet Function Tests (methods, statistics & numerical data)
  • Thromboxane B2 (analogs & derivatives, urine)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: