[Microsomal monooxygenases of the liver in mice with transplanted tumors].

Abstract

Hepatoma 22a and Ehrlich's tumor growth were shown to be accompanied by decrease in cytochrome P-450 level in liver of noninbred and C3HA mice, these changes being more pronounced as compared to solid neoplasms. Benzo(a)pyrene-hydroxylase and amidopyrine-N-demethylase activity varied with tumor pattern. It was not changed in cases of hepatoma 22a but decreased in mice bearing Ehrlich's tumor, particularly, in those with the ascitic form. The inhibition analysis using metyrapone and 7,8-benzoflavone identified phenobarbital and methylcholanthrene forms of benzo(a)pyrene-hydroxylase in murine liver; isoform profile was not significantly affected by tumor. Liver microsomal monooxygenases of tumor-bearing mice retained inducibility by 3-methylcholanthrene.

• Authors: M G Iakubovskaia, G A Belitskiĭ
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 35 Issue 12 Pg. 1461-4 ( 1989) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Mikrosomnye monooksigenazy pecheni u mysheĭ s perevivaemymi opukholiami.
• PMID: 2609542 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Benzoflavones
• Pyridines
• metapyrone
• Cytochrome P-450 Enzyme System
• Oxygenases
• Benzopyrene Hydroxylase

Topics

• Animals
• Benzoflavones (pharmacology)
• Benzopyrene Hydroxylase (analysis)
• Carcinoma, Ehrlich Tumor (enzymology)
• Cytochrome P-450 Enzyme System (analysis)
• Liver Neoplasms, Experimental (enzymology)
• Male
• Mice
• Mice, Inbred C3H
• Microsomes, Liver (enzymology)
• Oxygenases (analysis)
• Pyridines (pharmacology)