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Thymosin α 1 potentiates the release by CD8(+) cells of soluble factors able to inhibit HIV-1 and human T lymphotropic virus 1 infection in vitro.

AbstractBACKGROUND:
Thymosin α-1 (Tα1) exploits a specific action on lymphoid cells and is able to induce in peripheral blood mononuclear cells (PBMCs) a strong transcriptional response. CD8 antiviral factor activity plays a role in the control or prevention of HIV-1 infection by a non-cytolytic mechanism. The ability of Tα1 to modulate the release of antiretroviral soluble factors by CD8(+) cells was investigated.
METHODS:
Supernatants from lipopolysaccharide (LPS) stimulated CD8(+)-isolated cells treated with Tα1 were screened on in vitro infection of human monocyte-derived macrophages (MDMs) and PBMCs with HIV-1, and of PBMCs with human T lymphotropic virus 1 (HTLV-1). In CD8(+) cells, as well as in PBMCs of healthy donors as from HIV(+) individuals, a microarray analysis to assess the transcriptional response after treatment was performed.
RESULTS:
Tα1 potentiates the release, in LPS-stimulated CD8(+) cells, of soluble factors able to inhibit both in vitro HIV-1 infection of MDMs and PBMCs and in vitro HTLV-1 infection of PBMCs. A distinctive transcriptional profile was induced by Tα1 in PBMCs from HIV(+) donors.
CONCLUSIONS:
These findings suggest that Tα1 would represent a re-evaluated approach to antiretroviral therapy in combination with innovative treatments and with vaccine administration.
AuthorsClaudia Matteucci, Antonella Minutolo, Michela Pollicita, Emanuela Balestrieri, Sandro Grelli, Gabriella D'Ettorre, Vincenzo Vullo, Ilaria Bucci, Alessandra Luchini, Stefano Aquaro, Paola Sinibaldi-Vallebona, Beatrice Macchi, Carlo Federico Perno, Antonio Mastino, Enrico Garaci
JournalExpert opinion on biological therapy (Expert Opin Biol Ther) Vol. 15 Suppl 1 Pg. S83-100 ( 2015) ISSN: 1744-7682 [Electronic] England
PMID26094546 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiviral Agents
  • CD8 Antigens
  • Thymosin
  • Thymalfasin
Topics
  • Antiviral Agents (pharmacology, therapeutic use)
  • CD8 Antigens (immunology, metabolism)
  • Deltaretrovirus Infections (drug therapy, immunology, metabolism)
  • Drug Synergism
  • HIV Infections (immunology)
  • HIV-1 (drug effects, immunology)
  • Human T-lymphotropic virus 1 (drug effects, immunology, metabolism)
  • Humans
  • Leukocytes, Mononuclear (drug effects, immunology, metabolism)
  • Thymalfasin
  • Thymosin (analogs & derivatives, pharmacology, therapeutic use)

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