Outcomes of Renal Transplantation in Patients With Alport Syndrome.

Abstract

AIM:

We evaluated the outcomes of patients who underwent renal transplantation (Rtx) due to end-stage renal disease (ESRD) related to Alport syndrome in our study.

MATERIALS AND METHODS:

Twenty-five patients (female/male: 9 [36%]/16 [64%]) who underwent Rtx at our center between 2002 and 2014 were enrolled in the study. Mean ages of patients and donors (cadaveric/living: 8 [32%]/17 [68%]) were 28.2 ± 11.6 and 42.3 ± 15.8 years, respectively. As immunosuppressive therapy, tacrolimus plus mycophenolic acid were used for 17 (68%) patients and cyclosporin plus mycophenolic acid were used for 8 (32%) patients where induction therapy was basiliximab 20 mg (day 0 and 4) for 11 (44%) patients and anti-thymocyte globulin for 8 (32%) patients. Acute rejection was diagnosed using biopsy and evaluated with Banff classification. Analyses were performed by using SPSS 20.0 software with outcomes of mean 75.4 ± 31.4 months follow-up. Patient and graft survival were measured by using Kaplan-Meier survival curve and compared by using log-rank test.

RESULTS:

Graft survival rate was 89%, patient survival rate was 92.9%, and acute rejection rate was 12% (3 cases; 1 was cellular and 2 were antibody-mediated). Delayed graft function was observed in 4 (16%) cases, 1 patient (4%) had BK virus nephropathy and 2 (8%) patients required hemodialysis and had cytomegalovirus infection. At the last follow-up, mean serum creatinine level was 1.57 ± 1.23 mg/dL, spot urine protein creatinine ratio was 0.13 (0.04-1.84), and glomerular filtration rate was 71.7 ± 34.9 mL/min.

CONCLUSION:

Rtx is an effective and successful treatment modality for ESRD cases related to Alport syndrome.

• Authors: V T Yilmaz, A Dinckan, F Yilmaz, G Suleymanlar, H Kocak
• Journal: Transplantation proceedings (Transplant Proc) Vol. 47 Issue 5 Pg. 1377-81 (Jun 2015) ISSN: 1873-2623 [Electronic] United States
• PMID: 26093722 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Topics

• Adult
• Female
• Graft Rejection (epidemiology)
• Graft Survival
• Humans
• Incidence
• Kidney Failure, Chronic (etiology, surgery)
• Kidney Transplantation
• Male
• Nephritis, Hereditary (complications)
• Survival Rate (trends)
• Turkey (epidemiology)
• Young Adult