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Sorafenib continuation or discontinuation in patients with unresectable hepatocellular carcinoma after a complete response.

AbstractAIMS:
To assess the efficacy of continued administration of sorafenib for patients with unresectable hepatocellular carcinoma (HCC) treated with local regional therapy (LRT) after a complete response (CR), also, the adverse events of sorafenib after discontinuation of administration were observed.
METHODS:
Between April 2008 and May 2012, 956 consecutive patients with unresectable HCC treated with LRT (transarterial chemoembolization, radiofrequency ablation) combined with sorafenib were retrospectively investigated. Of these, 157 patients with a CR were enrolled: 102 of them continued to receive sorafenib (test group) and the other 55 stopped receiving sorafenib (control group).
RESULTS:
The median recurrence-free survival (RFS), post-complete response overall survival (pOS) and overall survival (OS) in the test and control groups were 11 months (95% CI: 6.1, 15.9), 25 months (95% CI: 20.7, 29.3) and 33 months (95% CI: 29.2, 36.8) and 12 months (95% CI: 10.4, 13.6), 28 months (95% CI 24.2, 31.8) and 34 months (95% CI: 30.8, 37.2) respectively. The differences in RFS, pOS and OS between the groups were not significant (P = 0.768, 0.797 and 0.730, respectively). The adverse events related to sorafenib resolved after discontinuation of administration and the quality of life (QoL) scores improved.
CONCLUSIONS:
Patients with unresectable HCC who achieved a CR did not benefit from continued sorafenib in terms of RFS, pOS or OS. The adverse events of sorafenib were reversible, and discontinuation of sorafenib may improve the QoL of patients who have achieved a CR.
AuthorsYingqiang Zhang, Wenzhe Fan, Kangshun Zhu, Ligong Lu, Sirui Fu, Jinhua Huang, Yu Wang, Jianyong Yang, Yonghui Huang, Wang Yao, Jiaping Li
JournalOncotarget (Oncotarget) Vol. 6 Issue 27 Pg. 24550-9 (Sep 15 2015) ISSN: 1949-2553 [Electronic] United States
PMID26093084 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

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