Esophageal Mast Cell Infiltration in a 32-Year-Old Woman with Noncardiac Chest Pain.

Abstract

Noncardiac chest pain (NCCP) is one of the most common esophageal symptoms and lacks a clearly defined mechanism. The most common cause of NCCP is gastroesophageal reflux disease (GERD). One of the accepted mechanisms of NCCP in a patient without GERD has been altered visceral sensitivity. Mast cells may play a role in visceral hypersensitivity in irritable bowel syndrome. In this case, a patient with NCCP and dysphagia who was unresponsive to proton pump inhibitor treatment had an increased esophageal mast cell infiltration and responded to 14 days of antihistamine and antileukotriene treatment. We suggest that there may be a relationship between esophageal symptoms such as NCCP and esophageal mast cell infiltration.

• Authors: Keol Lee, Hee Jin Kwon, In Young Kim, Kwai Han Yoo, Seulkee Lee, Yang Won Min, Poong-Lyul Rhee
• Journal: Gut and liver (Gut Liver) Vol. 10 Issue 1 Pg. 152-5 (Jan 2016) ISSN: 2005-1212 [Electronic] Korea (South)
• PMID: 26087786 (Publication Type: Case Reports, Journal Article)

Chemical References

• Histamine Antagonists
• Leukotriene Antagonists

Topics

• Adult
• Chest Pain (etiology)
• Esophageal Diseases (complications, drug therapy)
• Esophagus (cytology, pathology)
• Female
• Histamine Antagonists (therapeutic use)
• Humans
• Leukotriene Antagonists (therapeutic use)
• Mast Cells (metabolism)
• Mastocytosis (complications, drug therapy)