URAT1 gene polymorphisms influence uricosuric action of losartan in hypertensive patients with hyperuricemia.

Abstract

AIMS:

To explore the effect of urate transporter 1 (URAT1) polymorphisms on the hypertensive patients with hyperuricemia and the uricosuric action of losartan therapy among hypertensive patients with hyperuricemia.

METHODS:

101 hypertensive patients with hyperuricemia were detected the genotypes of URAT1 rs1529909 and rs3825016 and undergo a 2-weeks following losartan treatment. Before and after treatment, serum uric acid (SUA) and other clinical data were compared between different genotypes of URAT1 patients.

RESULTS:

The frequency of rs3825016 (C/T) CT genotype was significant higher in the hypertensive patients with hyperuricemia than that in the healthy controls (32.7 vs 18.8%; p = 0.02). After lorsatan treatment, the patients with the rs3825016 (C/T) or rs1529909 (T/C) mutant genotypes had lower decreased value (DV) of SUA compared with the patients who are wild-type of the variant (p = 0.001 and p < 0.001, respectively). Combined the two variants together, the DV of SUA in two variants both wild-type patients higher than that in the two variants mutant patients (p < 0.0001).

CONCLUSION:

These results suggest that URAT1 rs3825016 and rs1529909 polymorphisms influence the uricosuric action of losartan. Original submitted 20 August 2014; Revision submitted 15 April 2015.

• Authors: Hong Sun, Qiang Qu, Jian Qu, Xiao-Ya Lou, Yan Peng, Ying Zeng, Guo Wang
• Journal: Pharmacogenomics (Pharmacogenomics) Vol. 16 Issue 8 Pg. 855-63 (Jul 2015) ISSN: 1744-8042 [Electronic] England
• PMID: 26086348 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Organic Anion Transporters
• Organic Cation Transport Proteins
• SLC22A12 protein, human
• Uricosuric Agents
• Losartan

Topics

• Aged
• Female
• Genetic Association Studies
• Genotype
• Humans
• Hypertension (complications, drug therapy, genetics)
• Hyperuricemia (complications, drug therapy, genetics)
• Losartan (administration & dosage, adverse effects)
• Male
• Middle Aged
• Organic Anion Transporters (genetics)
• Organic Cation Transport Proteins (genetics)
• Polymorphism, Single Nucleotide
• Uricosuric Agents (administration & dosage, adverse effects)