An Isoflavone from Leiophyllum buxifolium and Its Antiproliferative Effect.

Abstract

A new C-methylisoflavone, isosideroxylin (1), and a known C-methylflavone, sideroxylin (2), were isolated from the EtOAc extract of the leaves of Leiophyllum buxifolium. The two compounds were evaluated with the sulforhodamine B assay for their antiproliferative effects against ER(-) MDA-MB-231 and ER(+) MCF-7 breast cancer cell lines and the NIH3T3 mouse fibroblast cell line. Isosideroxylin (1) displayed a selective antiproliferative effect against MDA-MB-231 cells.

• Authors: Dan Tian, John R Porter
• Journal: Journal of natural products (J Nat Prod) Vol. 78 Issue 7 Pg. 1748-51 (Jul 24 2015) ISSN: 1520-6025 [Electronic] United States
• PMID: 26086179 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Flavonoids
• Isoflavones
• sideroxylin

Topics

• Animals
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Cell Proliferation (drug effects)
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• Ericaceae (chemistry)
• Female
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Humans
• Isoflavones (chemistry, isolation & purification, pharmacology)
• MCF-7 Cells
• Mice
• Molecular Structure
• NIH 3T3 Cells
• New Jersey
• Plant Leaves (chemistry)