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HGF Guides T Cells into the Heart.

Abstract
Expression of distinct homing receptors guides adaptive immune cells to antigen-rich tissue. In this issue of Immunity, Komarowska et al. (2015) describe an autocrine loop that is initiated by cardiac-expressed hepatocyte growth factor to direct T cells into the heart during inflammation and cardiac transplant rejection.
AuthorsDennis Wolf, Jie Li, Klaus Ley
JournalImmunity (Immunity) Vol. 42 Issue 6 Pg. 979-81 (Jun 16 2015) ISSN: 1097-4180 [Electronic] United States
PMID26084015 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Chemical References
  • Hepatocyte Growth Factor
  • Proto-Oncogene Proteins c-met
Topics
  • Animals
  • Graft Rejection (prevention & control)
  • Heart (physiology)
  • Heart Transplantation
  • Hepatocyte Growth Factor (metabolism)
  • Humans
  • Proto-Oncogene Proteins c-met (metabolism)
  • T-Lymphocytes (physiology)

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