Applications of calixarenes in cancer chemotherapy: facts and perspectives.

Abstract

Research on the therapeutic applications of calixarene derivatives is an emerging area of interest. The anticancer activity of various functionalized calixarenes has been reported by several research groups. Due to their superior geometric shape, calixarenes can accommodate drug molecules by forming inclusion complexes. Controlled release of anticancer drugs by calixarenes might help in targeted chemotherapy. This review summarizes the anticancer potential of the calixarenes and their drug loading properties. The potential use of calixarenes in chemoradiotherapy is also highlighted in brief.

• Authors: Ali Yousaf, Shafida Abd Hamid, Noraslinda M Bunnori, A A Ishola
• Journal: Drug design, development and therapy (Drug Des Devel Ther) Vol. 9 Pg. 2831-8 ( 2015) ISSN: 1177-8881 [Electronic] New Zealand
• PMID: 26082613 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Delayed-Action Preparations
• Calixarenes

Topics

• Animals
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Calixarenes (administration & dosage, therapeutic use)
• Chemoradiotherapy (methods)
• Delayed-Action Preparations
• Humans
• Neoplasms (drug therapy)