Abstract | BACKGROUND: METHODS: HepG2 cells were treated with palmitate for 24 h to induce cellular hepatic steatosis and insulin resistance. The cells were then treated with Oligonol at subtoxic concentrations and examined for lipid metabolism, cytokine production, and insulin signaling using quantitative RT-PCR and western blot analysis. RESULTS:
Oligonol treatment reversed the palmitate-induced intracellular lipid accumulation, down regulated the expression of lipogenic genes, and up-regulated genes for fatty acid degradation. Oligonol restored insulin sensitivity, as was determined by the phosphorylation states of IRS-1. Oligonol also inhibited STAT3-SOCS3 signaling and increased AMPK phosphorylation in HepG2 cells. CONCLUSION:
|
Authors | Jae-Yeo Park, Younghwa Kim, Jee Ae Im, Hyangkyu Lee |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 15
Pg. 185
(Jun 16 2015)
ISSN: 1472-6882 [Electronic] England |
PMID | 26077338
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Phenols
- oligonol
- Catechin
|
Topics |
- Catechin
(analogs & derivatives, pharmacology)
- Fatty Liver
(metabolism)
- Hep G2 Cells
- Humans
- Insulin Resistance
- Lipid Metabolism
(drug effects)
- Models, Biological
- Phenols
(pharmacology)
|