Renin Genetic Polymorphism in Heart Failure Patients.

Abstract

BACKGROUND:

Genetic polymorphism of renin-angiotensin-aldosterone system affects the pathogenesis of hypertension (HTN), ischemic heart disease (IHD) and heart failure (HF). The purpose of our study is to analyze A/G renin genetic polymorphism in heart failure patients.

METHODS:

We investigated renin polymorphism in 83 subjects hospitalized in the Cardiology Department of the Rehabilitation Hospital Cluj-Napoca, using the PCR amplification method. 43 patients were diagnosed with heart failure [NYHA III-IV class], and 40 subjects without cardiovascular disease (control group). The NT-proBNP and the presence of cardiovascular risk factors were assessed.

RESULTS:

Heart failure etiology was IHD in 60.46% of patients. The average value of NT-pro BNP was 2991.24 ± 2034.6 pg/ml. As it was expected, HF patients presented low lipid levels: total cholesterol = 162.36 ± 38.28 mg/dl, LDL-Cholesterol = 104.88 ± 27.60 mg/dl, triglycerides= 109.12 ± 55.84 mg/dl, HDL-Co = 35.68 ± 9.55 mg/dl. A/G renin genetic polymorphism [with pathogenic potential] in heart failure patients was of 60.46% (homozygote 4.65% and heterozygote 55.81%). Conversely, pathogenic mutations were found only in 38.46% of hypertensive patients, but also in 55.88% and 22.22% patients with obesity/overweight and diabetes. The heterozygote form was found in only 37.5% of control subjects.

CONCLUSION:

This study showed no involvement of A/G renin polymorphisms in the pathogenesis of HF.

• Authors: Dana Pop, Adela-Viviana Sitar-Tăut, Lucia Procopciuc, Mirela Cebanu, M Zdrenghea, D Zdrenghea
• Journal: Romanian journal of internal medicine = Revue roumaine de medecine interne (Rom J Intern Med) 2015 Jan-Mar Vol. 53 Issue 1 Pg. 37-43 ISSN: 1220-4749 [Print] Germany
• PMID: 26076559 (Publication Type: Journal Article)

Chemical References

• Renin

Topics

• Adult
• Aged
• Case-Control Studies
• Female
• Heart Failure (genetics)
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)
• Renin (genetics)