[Pharmacokinetic and clinical studies on cefodizime in obstetrics and gynecology].

Abstract

Cefodizime (CDZM), a new cephem antibiotic, was studied in terms of its pharmacokinetics and clinical efficacy in the field of obstetrics and gynecology, and the results are summarized as follows: Concentrations of CDZM in serum and genital tissues following 1 g drip infusion (30 min.) were determined and good penetration of CDZM into tissues was recognized. The maximum level in uterine arterial serum was 56.25 micrograms/ml and maximum tissue levels ranged 23.56-40.64 micrograms/g which were above its MIC80's for main pathogenic organisms. Peak concentrations of CDZM in pelvic dead space exudates following 1 g intravenous bolus injection or drip infusion ranged 6.25-6.52 micrograms/ml. The clinical efficacy of CDZM in 17 cases of obstetrical and gynecological infections was investigated using a dose of 1-3 g daily. The clinical efficacy rate was 88.2% (15/17 cases). Bacteriologically, the eradication rate was 83.3%. No side effects or abnormal laboratory test values were observed.

• Authors: N Cho, K Fukunaga, K Kunii
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 42 Issue 10 Pg. 2069-81 (Oct 1989) ISSN: 0368-2781 [Print] Japan
• PMID: 2607597 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cefotaxime
• cefodizime

Topics

• Adult
• Aged
• Bacteria (drug effects)
• Bacterial Infections (drug therapy)
• Cefotaxime (administration & dosage, analogs & derivatives, pharmacokinetics, pharmacology)
• Drug Evaluation
• Drug Resistance, Microbial
• Female
• Genital Diseases, Female (drug therapy)
• Genitalia, Female (metabolism)
• Humans
• Infusions, Intravenous
• Injections, Intravenous
• Middle Aged
• Tissue Distribution