| Abstract | Cefodizime (CDZM), a new cephem antibiotic, was studied in terms of its pharmacokinetics and clinical efficacy in the field of obstetrics and gynecology, and the results are summarized as follows: Concentrations of CDZM in serum and genital tissues following 1 g drip infusion (30 min.) were determined and good penetration of CDZM into tissues was recognized. The maximum level in uterine arterial serum was 56.25 micrograms/ml and maximum tissue levels ranged 23.56-40.64 micrograms/g which were above its MIC80's for main pathogenic organisms. Peak concentrations of CDZM in pelvic dead space exudates following 1 g intravenous bolus injection or drip infusion ranged 6.25-6.52 micrograms/ml. The clinical efficacy of CDZM in 17 cases of obstetrical and gynecological infections was investigated using a dose of 1-3 g daily. The clinical efficacy rate was 88.2% (15/17 cases). Bacteriologically, the eradication rate was 83.3%. No side effects or abnormal laboratory test values were observed. |
| Authors | N Cho, K Fukunaga, K Kunii
(Affiliation: Department of Obstetrics and Gynecology, School of Medicine, Showa University.)
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| Journal | The Japanese journal of antibiotics
(Jpn J Antibiot)
Vol. 42
Issue 10
Pg. 2069-81
(Oct 1989)
ISSN: 0368-2781 JAPAN |
| PMID | 2607597
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
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| Topics |
- Adult
- Aged
- Bacteria
(drug effects)
- Bacterial Infections
(drug therapy)
- Cefotaxime
(administration & dosage, analogs & derivatives, pharmacokinetics, pharmacology)
- Drug Evaluation
- Drug Resistance, Microbial
- Female
- Genital Diseases, Female
(drug therapy)
- Genitalia, Female
(metabolism)
- Humans
- Infusions, Intravenous
- Injections, Intravenous
- Middle Aged
- Tissue Distribution
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