Abstract | BACKGROUND: Invasive cases of extramammary Paget's disease have a poor prognosis, owing to its rapid progression and resistance to irradiation and chemotherapy. Morton et al. introduced a technique to identify sentinel lymph nodes by local injection of vital dyes and reported its benefit for managing the progress of malignant melanoma. OBJECTIVES: MATERIALS & METHODS: Eighteen patients with primary extramammary Paget's disease were enrolled in the study. The precise location of sentinel lymph nodes was visualized using either intraoperative patent blue dye injection or indocyanine green dye injection in combination with a hand-held gamma-detecting probe after a 99mTc phytate injection. RESULTS: Of the 18 patients, sentinel lymph node metastasis was identified in 2 (Cases 2 and 15) of the 2 patients with deep invasion and in 1 (Case 12) of the 7 patients with minimal dermal invasion, however, it was absent in 9 patients who had been categorized into the intraepidermal group. CONCLUSION:
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Authors | Kenji Kusatake, Yuji Harada, Kazuo Mizumoto, Sakae Kaneko, Hiroyuki Niihara, Yuko Chinuki, Eishin Morita |
Journal | European journal of dermatology : EJD
(Eur J Dermatol)
Vol. 25
Issue 2
Pg. 156-61
(Apr 2015)
ISSN: 1952-4013 [Electronic] France |
PMID | 26075323
(Publication Type: Journal Article)
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Chemical References |
- Coloring Agents
- Organotechnetium Compounds
- Radiopharmaceuticals
- Rosaniline Dyes
- technetium phytate
- Phytic Acid
- sulfan blue
- Indocyanine Green
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Topics |
- Aged
- Aged, 80 and over
- Axilla
- Coloring Agents
- Female
- Genital Neoplasms, Female
(pathology, surgery)
- Genital Neoplasms, Male
(pathology, surgery)
- Groin
- Humans
- Indocyanine Green
- Lymph Node Excision
- Lymph Nodes
(pathology, surgery)
- Lymphatic Metastasis
- Lymphoscintigraphy
- Male
- Middle Aged
- Neoplasm Invasiveness
- Organotechnetium Compounds
- Paget Disease, Extramammary
(secondary, surgery)
- Phytic Acid
- Radiopharmaceuticals
- Rosaniline Dyes
- Sentinel Lymph Node Biopsy
(methods)
- Skin Neoplasms
(pathology, surgery)
- Treatment Outcome
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