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Ginger and Zingerone Ameliorate Lipopolysaccharide-Induced Acute Systemic Inflammation in Mice, Assessed by Nuclear Factor-κB Bioluminescent Imaging.

Abstract
Ginger is a commonly used spice in cooking. In this study, we comprehensively evaluated the anti-inflammatory activities of ginger and its component zingerone in lipopolysaccharide (LPS)-induced acute systemic inflammation in mice via nuclear factor-κB (NF-κB) bioluminescent imaging. Ginger and zingerone significantly suppressed LPS-induced NF-κB activities in cells in a dose-dependent manner, and the maximal inhibition (84.5% ± 3.5% and 96.2% ± 0.6%) was observed at 100 μg/mL ginger and zingerone, respectively. Moreover, dietary ginger and zingerone significantly reduced LPS-induced proinflammatory cytokine production in sera by 62.9% ± 18.2% and 81.3% ± 6.2%, respectively, and NF-κB bioluminescent signals in whole body by 26.9% ± 14.3% and 38.5% ± 6.2%, respectively. In addition, ginger and zingerone suppressed LPS-induced NF-κB-driven luminescent intensities in most organs, and the maximal inhibition by ginger and zingerone was observed in small intestine. Immunohistochemical staining further showed that ginger and zingerone decreased interleukin-1β (IL-1β)-, CD11b-, and p65-positive areas in jejunum. In conclusion, our findings suggested that ginger and zingerone were likely to be broad-spectrum anti-inflammatory agents in most organs that suppressed the activation of NF-κB, the production of IL-1β, and the infiltration of inflammatory cells in mice.
AuthorsChien-Yun Hsiang, Hui-Man Cheng, Hsin-Yi Lo, Chia-Cheng Li, Pei-Chi Chou, Yu-Chen Lee, Tin-Yun Ho
JournalJournal of agricultural and food chemistry (J Agric Food Chem) Vol. 63 Issue 26 Pg. 6051-8 (Jul 08 2015) ISSN: 1520-5118 [Electronic] United States
PMID26073629 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • IL1B protein, mouse
  • Interleukin-1beta
  • Lipopolysaccharides
  • NF-kappa B
  • Plant Extracts
  • zingerone
  • Guaiacol
Topics
  • Acute Disease (therapy)
  • Animals
  • Anti-Inflammatory Agents (administration & dosage)
  • Female
  • Ginger (chemistry)
  • Guaiacol (administration & dosage, analogs & derivatives)
  • Humans
  • Inflammation (diagnosis, drug therapy, genetics, immunology)
  • Interleukin-1beta (genetics)
  • Lipopolysaccharides (adverse effects, immunology)
  • Mice
  • NF-kappa B (chemistry, genetics, immunology)
  • Plant Extracts (administration & dosage)
  • Whole Body Imaging

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