Dysgeusia in a Patient with Guillain-Barré Syndrome Associated with Acute Hepatitis E: A Case Report and Literature Review.

Abstract

Guillain-Barré syndrome (GBS) is usually triggered by viral or bacterial infection. In addition, it was recently reported that infection with hepatitis E virus (HEV) also causes GBS. A 49-year-old man presented with acute-onset paralysis in all extremities and dysgeusia during an episode of acute hepatitis. Serological tests showed the presence of anti-HEV IgM antibodies and HEV-RNA in the serum. As an electrophysiological examination showed acute demyelinating polyradiculoneuropathy, the patient was diagnosed as HEV-associated GBS. Following the initiation of treatment with intravenous immunoglobulin, his paralysis and dysgeusia rapidly improved. This case suggests that HEV-associated GBS may rarely be complicated by dysgeusia.

• Authors: Masa-Aki Higuchi, Jiro Fukae, Jun Tsugawa, Shinji Ouma, Kazuaki Takahashi, Shunji Mishiro, Yoshio Tsuboi
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 54 Issue 12 Pg. 1543-6 ( 2015) ISSN: 1349-7235 [Electronic] Japan
• PMID: 26073247 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Immunoglobulins, Intravenous
• Immunologic Factors
• RNA, Viral

Topics

• Acute Disease
• Dysgeusia (virology)
• Guillain-Barre Syndrome (diagnosis, drug therapy, immunology)
• Hepatitis E (diagnosis, drug therapy, immunology)
• Hepatitis E virus (genetics, isolation & purification)
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Immunologic Factors (therapeutic use)
• Male
• Middle Aged
• Odds Ratio
• Paralysis (complications, physiopathology, virology)
• RNA, Viral (blood)