[Lung disease in adult common variable immunodeficiency].

Abstract

INTRODUCTION:

Common variable immunodeficiency (CVID) is characterized by a defect in antibody production and may be complicated by infectious or non-infectious respiratory disease.

BACKGROUND:

In addition to recurrent infectious complications, mainly due to encapsulated bacteria, CVID may be complicated by diffuse infiltrative, non-infectious lung disease. The latter may be related to granulomatosis, lymphoid interstitial pneumonia, follicular bronchiolitis, follicular nodular hyperplasia, organizing pneumonia or lymphoma. Different lymphoid histological lesions can co-exist and form a new entity called GLILD (granulomatous lymphocytic interstitial lung disease), which is associated with a poor prognosis. Replacement of immunoglobulins significantly decreases the frequency and severity of infections but has no impact on the non-infectious complications.

OUTLOOK:

Studies are needed to determine the modalities of follow-up and better understand the long-term progress of GLILD. These studies should improve the management of GLILD in the context of immunosuppressive treatments, which increase the risk of infection in CVID.

CONCLUSION:

The identification of GLILD, which reflects a variable histological spectrum, rather than a well-defined entity, necessitates revising the approach to diffuse infiltrative lung diseases in CVID.

• Authors: J Hadjadj, M Malphettes, C Fieschi, E Oksenhendler, A Tazi, A Bergeron
• Journal: Revue des maladies respiratoires (Rev Mal Respir) Vol. 32 Issue 10 Pg. 991-1001 (Dec 2015) ISSN: 1776-2588 [Electronic] France
• Vernacular Title: Atteintes respiratoires au cours du déficit immunitaire commun variable de l'adulte.
• PMID: 26071128 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2015 SPLF. Published by Elsevier Masson SAS. All rights reserved.

Topics

• Adult
• Common Variable Immunodeficiency (complications)
• Humans
• Lung Diseases (diagnosis, etiology)
• Lung Diseases, Interstitial (etiology)