Nicotine and estrogen metabolism--possible implications of smoking for growth and outcome of treatment of hormone-dependent cancer? Discussion of experimental results.

Abstract

The combination treatment of hormone-dependent autochthonous mammary carcinomas in the rat with nicotine plus HECNU, a water-soluble nitrosourea, resulted in a potentiation of antitumor action. Nicotine and its metabolite cotinine are strong inhibitors of the aromatase. With regard to investigations in smoking women, suggesting a decreased endogenous estrogen production, our results indicate that smoking might influence growth and treatment results of hormone-dependent human cancer.

• Authors: W J Zeller, M R Berger
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 115 Issue 6 Pg. 601-3 ( 1989) ISSN: 0171-5216 [Print] Germany
• PMID: 2606936 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Estrogens
• Nicotine
• Aromatase

Topics

• Animals
• Aromatase (metabolism)
• Chemical Phenomena
• Chemistry
• Drug Synergism
• Estrogens (metabolism, pharmacology)
• Female
• Humans
• Mammary Neoplasms, Experimental (drug therapy, metabolism, pathology)
• Microsomes (drug effects, enzymology)
• Neoplasms, Hormone-Dependent (drug therapy, metabolism, pathology)
• Nicotine (metabolism, pharmacology)
• Rats
• Smoking (metabolism)