Polymorphisms of FGFR1 in HBV-related hepatocellular carcinoma.

Abstract

Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers in China. It is important to understand the genetic mechanisms underlying the development and progression of HBV-related HCC and to identify new biomarkers for clinical treatment. The important role of fibroblast growth factor receptors (FGFRs) has been widely recognized in many types of cancers, but the association between FGFR polymorphisms and HCC carcinogenesis has been rarely reported. In this study, 199 patients with HBV-associated cirrhosis, 203 with HBV-associated HCC, and 184 healthy controls with no liver diseases were enrolled as participants. Using SNaPshot assays, five SNPs (rs13317, rs7825208, rs1047057, rs1047111, and rs1966265) of growth factor receptor genes were genotyped. Our results showed that the G/A and G/G genotypes at rs7825208 of FGFR1 were negatively correlated with HBV-related HCC (odds ratio (OR) = 0.45, 95% confidence interval (CI) = 0.22-0.93, P = 0.027). However, after Bonferroni correction, these significant differences no longer existed (P > 0.05). Our results indicated that these five polymorphisms of fibroblast growth factor receptor genes do not play any independent roles in the tumorigenesis and progression of HBV-related HCC in Han Chinese patients.

• Authors: Haiyang Xie, Chunyang Xing, Bajin Wei, Xiao Xu, Liming Wu, Jian Wu, Leiming Chen, Guoqiang Cao, Hai Chen, Xueqin Meng, Shengyong Yin, Lin Zhou, Shusen Zheng
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 36 Issue 11 Pg. 8881-6 (Nov 2015) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 26069105 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• FGFR1 protein, human
• Receptor, Fibroblast Growth Factor, Type 1

Topics

• Adult
• Carcinogenesis
• Carcinoma, Hepatocellular (genetics, pathology, virology)
• Female
• Fibrosis (genetics, pathology, virology)
• Genetic Association Studies
• Hepatitis B (genetics, pathology, virology)
• Hepatitis B virus (genetics, pathogenicity)
• Humans
• Liver Neoplasms (genetics, pathology, virology)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Receptor, Fibroblast Growth Factor, Type 1 (genetics)