Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut.
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| Abstract |
ω3 polyunsaturated fatty acids (PUFAs) have anti-allergic and anti-inflammatory properties, but the immune-metabolic progression from dietary oil remains to be investigated. Here we identified 17,18-epoxyeicostetraenoic acid (17,18-EpETE) as an anti-allergic metabolite generated in the gut from dietary ω3 α-linolenic acid (ALA). Biochemical and imaging mass spectrometry analyses revealed increased ALA and its metabolites, especially eicosapentaenoic acid (EPA), in the intestines of mice receiving ALA-rich linseed oil (Lin-mice). In murine food allergy model, the decreased incidence of allergic diarrhea in Lin-mice was due to impairment of mast cell degranulation without affecting allergen-specific serum IgE. Liquid chromatography-tandem mass spectrometry-based mediator lipidomics identified 17,18-EpETE as a major ω3 EPA-derived metabolite generated from dietary ALA in the gut, and 17,18-EpETE exhibits anti-allergic function when administered in vivo. These findings suggest that metabolizing dietary ω3 PUFAs generates 17,18-EpETE, which is an endogenous anti-allergic metabolite and potentially is a therapeutic target to control intestinal allergies.
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| Authors | Jun Kunisawa, Makoto Arita, Takahiro Hayasaka, Takashi Harada, Ryo Iwamoto, Risa Nagasawa, Shiori Shikata, Takahiro Nagatake, Hidehiko Suzuki, Eri Hashimoto, Yosuke Kurashima, Yuji Suzuki, Hiroyuki Arai, Mitsutoshi Setou, Hiroshi Kiyono |
| Journal | Scientific reports (Sci Rep) Vol. 5 Pg. 9750 (Jun 11 2015) ISSN: 2045-2322 [Electronic] England |
| PMID | 26065911 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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