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An Animal Model Using Metallic Ions to Produce Autoimmune Nephritis.

Abstract
Autoimmune nephritis triggered by metallic ions was assessed in a Long-Evans rat model. The parameters evaluated included antinuclear autoantibody production, kidney damage mediated by immune complexes detected by immunofluorescence, and renal function tested by retention of nitrogen waste products and proteinuria. To accomplish our goal, the animals were treated with the following ionic metals: HgCl2, CuSO4, AgNO3, and Pb(NO3)2. A group without ionic metals was used as the control. The results of the present investigation demonstrated that metallic ions triggered antinuclear antibody production in 60% of animals, some of them with anti-DNA specificity. Furthermore, all animals treated with heavy metals developed toxic glomerulonephritis with immune complex deposition along the mesangium and membranes. These phenomena were accompanied by proteinuria and increased concentrations of urea. Based on these results, we conclude that metallic ions may induce experimental autoimmune nephritis.
AuthorsRoxana Ramírez-Sandoval, Nayeli Luévano-Rodríguez, Mayra Rodríguez-Rodríguez, María Elena Pérez-Pérez, Sergio Saldívar-Elias, Reinaldo Gurrola-Carlos, Esperanza Avalos-Díaz, Juan José Bollain-y-Goytia, Rafael Herrera-Esparza
JournalJournal of immunology research (J Immunol Res) Vol. 2015 Pg. 269610 ( 2015) ISSN: 2314-7156 [Electronic] Egypt
PMID26064998 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Antinuclear
  • Ions
  • Metals
Topics
  • Animals
  • Antibodies, Antinuclear (immunology)
  • Autoimmune Diseases (chemically induced, immunology)
  • Disease Models, Animal
  • Fluorescent Antibody Technique (methods)
  • Glomerulonephritis (chemically induced, immunology)
  • Ions (adverse effects, immunology)
  • Kidney (drug effects, immunology)
  • Kidney Glomerulus (drug effects, immunology)
  • Male
  • Metals (adverse effects, immunology)
  • Nephritis (chemically induced, immunology)
  • Proteinuria (immunology)
  • Rats
  • Rats, Long-Evans

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