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Effects of minocycline-HCl paste root conditioning on periodontal surgery: in vitro and in vivo studies.

AbstractOBJECTIVES:
This study was aimed to investigate effects of 2% minocycline-HCl paste root conditioning on periodontal surgery.
MATERIALS AND METHODS:
In vitro, cementum slices affected by periodontitis were randomly conditioned with 2% minocycline-HCl paste, 2% minocycline-HCl liquid, and 0.9% saline. NIH3T3 cells were cultured and attached to the each slide, and the viability and proliferation of cells were observed; In vivo, 21 deep periodontal pockets were treated by periodontal surgery, and the exposed root surfaces were randomly conditioned with 2% minocycline-HCl paste or 0.9% saline. The periodontal parameters were measured at baseline, after 3 and 6 months of periodontal surgery.
RESULTS:
In vitro, NIH3T3 cell showed better viability and proliferation at 3, 5, and 7 day in groups conditioned with minocycline-HCl than the group conditioned with 0.9% saline (at 3 day (P < 0.05); at 7 day (P < 0.01)) Minimal differences were found between minocycline-HCl paste and liquid groups; In vivo, 3 months after periodontal surgery, the greater CAL reduction was found in the minocycline-HCl treated group than in the control group (P < 0.05). The similar results were found for both CAL and PD (P < 0.05; P < 0.05) between two groups at 6 months after surgery. PI and SBI variations showed no statistical differences between two groups after periodontal surgery.
CONCLUSION:
Our results suggested that root conditioning with minocycline-HCl paste during periodontal surgery improve the periodontal healing, which may be associated with the promotion of the periodontal cell attachment and growth onto the root surfaces.
AuthorsHuihui Zhang, Xi Yang, Chengzhang Li, Shuhuan Shang, Jiaxi Wang
JournalInternational journal of clinical and experimental medicine (Int J Clin Exp Med) Vol. 8 Issue 3 Pg. 4080-6 ( 2015) ISSN: 1940-5901 [Print] United States
PMID26064313 (Publication Type: Journal Article)

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