Abstract | BACKGROUND: MATERIAL AND METHODS: Randomized controlled trials with zoledronic acid treatment for osteoporosis were retrieved from PubMed, EMBASE and clinicaltrials.gov. The risk ratio with 95% confidence interval (RR, 95% CI) was calculated to evaluate the effect of zoledronic acid treatment on incidence of fracture. Data on changes in bone mineral density (BMD) following zoledronic acid (ZOL) treatment was also extracted. STATA software was used for all the statistical analyses. RESULTS: Significant reduction in the incidence of both vertebral and nonvertebral fracture was observed following ZOL treatment, as seen from the values for RR with 95% CI (RR 0.24 and 95% CI 0.15 to 0.40 for vertebral fractures; RR 0.76 and 95% CI 0.67 to 0.86 for nonvertebral fractures). BMD was also seen to be increased after ZOL treatment. CONCLUSION: Ourmeta-analysis showed that zoledronic acid was effective in reducing the incidence of vertebral fractures as well as nonvertebral fractures, including hip fractures. Significant increase in bone mineral density (BMD) was also observed in patients administered ZOL as compared to placebo.
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Authors | Minyan Liu, Lei Guo, Yu Pei, Nan Li, Mengmeng Jin, Lichao Ma, Yu Liu, Banruo Sun, Chunlin Li |
Journal | International journal of clinical and experimental medicine
(Int J Clin Exp Med)
Vol. 8
Issue 3
Pg. 3855-61
( 2015)
ISSN: 1940-5901 [Print] United States |
PMID | 26064284
(Publication Type: Journal Article)
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