Childhood Hepatosplenic T-cell Lymphoma with Skin Involvement.

Abstract

BACKGROUND:

Hepatosplenic T-cell lymphoma is a rare malignancy in childhood.

CASE CHARACTERISTICS:

A 12-year-old boy who presented a pyrexia of unknown origin, multiple skin and lesions and marked hepatosplenomegaly.

OBSERVATION:

Bone marrow aspirate cytology showed no blast cells. Splenectomy was done, and spleen showed infiltration with atypical lymphoid cells positive for CD3, CD8 and T-cell-restricted intracellular antigen.

OUTCOME:

The skin rash of patient subsided with chemotherapy.

MESSAGE:

Skin involvement may be an unusual clinical manifestation of hepatosplenic T-cell lymphoma.

• Authors: Xia Guo, Qiang Li, Yi-Ping Zhu
• Journal: Indian pediatrics (Indian Pediatr) Vol. 52 Issue 5 Pg. 427-8 (May 2015) ISSN: 0974-7559 [Electronic] India
• PMID: 26061932 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Child
• Humans
• Liver Neoplasms
• Lymphoma, T-Cell
• Male
• Skin (pathology)
• Splenic Neoplasms