Abstract | OBJECTIVE: DESIGN: Post Hoc analysis including data collected over 12 months of follow-up from 131 HIV-infected MSM receiving antiretroviral therapy and screened for incident bacterial STI every 3 months. METHODS: Genital secretions collected at baseline were used to measure herpesvirus replication and inflammatory cytokines. Baseline predictors of STI were determined using survival analysis of time to incident STI. RESULTS: All participants were seropositive for cytomegalovirus (CMV), and 52% had detectable genital CMV at baseline. Thirty-five individuals acquired STI during follow-up, sometimes with multiple pathogen (17 syphilis, 21 gonorrhea, 14 chlamydia). Syphilis acquisition was associated with genital CMV replication at baseline (19.1% CMV-shedders versus 4.8% non-shedders, p=0.03) and younger age (p=0.02). Lower seminal MCP-1 was associated with higher seminal CMV levels and with syphilis acquisition (p<0.01). For syphilis acquisition, in multivariable Cox-Proportional Hazard model adjusted hazard rates were 3.56 (95%CI:1.00-12.73) for baseline CMV replication and 2.50 (0.92-6.77) for younger age. CONCLUSIONS: This post hoc analysis suggest that CMV-associated decrease in seminal MCP-1 levels might predispose HIV-infected MSM to syphilis acquisition, but not other STI. Future studies should determine underlying mechanisms and if a causal association exists.
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Authors | Sara Gianella, Davey M Smith, Eric S Daar, Michael P Dube, Andrea Lisco, Christophe Vanpouille, Leonid Margolis, Richard H Haubrich, Sheldon R Morris |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 6
Pg. e0130410
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26061824
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- AIDS-Related Opportunistic Infections
(diagnosis, epidemiology)
- Adult
- Cytokines
(metabolism)
- Cytomegalovirus
(isolation & purification, physiology)
- Cytomegalovirus Infections
(diagnosis, epidemiology)
- HIV-1
- Homosexuality, Male
- Humans
- Male
- Middle Aged
- Semen
(metabolism, virology)
- Syphilis
(diagnosis, epidemiology)
- Virus Replication
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