Abstract | BACKGROUND AND PURPOSE: METHODS: Nampt transgenic (Nampt-Tg) mice and H247A mutant enzymatic-dead Nampt transgenic (ΔNampt-Tg) mice were subjected with experimental cerebral ischemia by middle cerebral artery occlusion. Activation of neural stem cells, neurogenesis, and neurological function recovery were measured. Besides, nicotinamide mononucleotide and NAD, two chemical enzymatic product of Nampt, were administrated in vivo and in vitro. RESULTS: CONCLUSIONS: Our data demonstrate that the Nampt- NAD cascade may act as a centralizing switch in postischemic regeneration through controlling different sirtuins and therefore represent a promising therapeutic target for long-term recovery of ischemic stroke.
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Authors | Yan Zhao, Yun-Feng Guan, Xiao-Ming Zhou, Guo-Qiang Li, Zhi-Yong Li, Can-Can Zhou, Pei Wang, Chao-Yu Miao |
Journal | Stroke
(Stroke)
Vol. 46
Issue 7
Pg. 1966-74
(Jul 2015)
ISSN: 1524-4628 [Electronic] United States |
PMID | 26060246
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 American Heart Association, Inc. |
Chemical References |
- Cytokines
- NAD
- Nicotinamide Phosphoribosyltransferase
- nicotinamide phosphoribosyltransferase, mouse
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Topics |
- Animals
- Brain Ischemia
(drug therapy, metabolism, pathology)
- Cytokines
(biosynthesis)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- NAD
(pharmacology, therapeutic use)
- Nerve Regeneration
(drug effects, physiology)
- Neurogenesis
(drug effects, physiology)
- Nicotinamide Phosphoribosyltransferase
(biosynthesis)
- Signal Transduction
(drug effects, physiology)
- Stroke
(drug therapy, metabolism, pathology)
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