Astragalin Attenuates Allergic Inflammation in a Murine Asthma Model.

Abstract

The present study aimed to determine the protective effects and the underlying mechanisms of astragalin (AG) on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. Our study demonstrated that AG inhibited OVA-induced increases in eosinophil count; IL-4, IL-5, IL-13, and IgE were recovered in bronchoalveolar lavage fluid, and increased IFN-γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that AG substantially inhibited OVA-induced eosinophilia in lung tissue. Western blot analysis demonstrated that AG treatments markedly inhibited OVA-induced SOCS-3 expression and enhancement of SOCS-5 expression in an asthma model. Our findings support the possible use of AG as a therapeutic drug for patients with allergic asthma.

• Authors: Jiping Liu, Yue Cheng, Xiaoshuang Zhang, Xue Zhang, Shuxian Chen, Zongmiao Hu, Chunmei Zhou, Enhu Zhang, Shiping Ma
• Journal: Inflammation (Inflammation) Vol. 38 Issue 5 Pg. 2007-16 (Oct 2015) ISSN: 1573-2576 [Electronic] United States
• PMID: 26059910 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Inflammation Mediators
• Kaempferols
• Ovalbumin
• astragalin

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Asthma (chemically induced, drug therapy, metabolism)
• Female
• Inflammation (chemically induced, drug therapy, metabolism)
• Inflammation Mediators (antagonists & inhibitors, metabolism)
• Kaempferols (therapeutic use)
• Mice
• Mice, Inbred BALB C
• Ovalbumin (toxicity)