Abstract | BACKGROUND: METHODS: We examined the 1-year incidence of recurrent cardiovascular (CV) events in the subgroup of patients with prior chronic angina (n = 3565) enrolled in the randomized, double-blind, placebo-controlled Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation ACS ( MERLIN)-Thrombolysis In Myocardial Infarction (TIMI) 36 trial who did or did not have a PCI within 30 days of the index event. RESULTS:
Ranolazine reduced the risk of recurrent ischemia following admission regardless of whether patients had (hazard ratio [HR], 0.69; 95% confidence interval [CI] 0.51-0.92] or did not have PCI (HR, 0.81; 95% CI, 0.66-0.99; P interaction = 0.39). CV death, myocardial infarction, and recurrent ischemia were similarly lower with ranolazine in the PCI group (HR, 0.71; 95% CI, 0.55-0.91) vs the non-PCI group (HR, 0.91; 95% CI, 0.78-1.06; P interaction = 0.10), with a nominally significant decrease in CV death (HR, 0.39; 95% CI, 0.16-0.93) in the PCI group vs no difference in the non-PCI group (HR, 1.19; 95% CI, 0.89-1.59; P interaction = 0.02). CONCLUSIONS: In patients with chronic angina, ranolazine reduced recurrent ischemic events, regardless of whether patients did or did not receive PCI within 30 days of a non-ST-segment ACS.
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Authors | Jorge A Gutierrez, Ewa Karwatowska-Prokopczuk, Sabina A Murphy, Luiz Belardinelli, Ramin Farzaneh-Far, Gennyne Walker, David A Morrow, Benjamin M Scirica |
Journal | Clinical cardiology
(Clin Cardiol)
Vol. 38
Issue 8
Pg. 469-75
(Aug 2015)
ISSN: 1932-8737 [Electronic] United States |
PMID | 26059896
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2015 Wiley Periodicals, Inc. |
Chemical References |
- Sodium Channel Blockers
- Ranolazine
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Topics |
- Acute Coronary Syndrome
(drug therapy, surgery)
- Aged
- Angina Pectoris
(drug therapy)
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Percutaneous Coronary Intervention
(methods)
- Ranolazine
(therapeutic use)
- Recurrence
- Sodium Channel Blockers
(therapeutic use)
- Treatment Outcome
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