Abstract |
The stem- and root-bark of Erythrophleum ivorense (A Chev., family, Fabaceae) are routinely employed in the West African traditional medicine to treat inflammation and a variety of other disease conditions. Although the chemistry and pharmacology of cassaine-type diterpene alkaloids isolated from the stem-bark of the plant are fairly established, the root-bark has not yet been investigated. In the present study, the crude aqueous-alcohol extract of the root-bark was demonstrated to display a time- and dose (30-300 mg/kg p.o.)-dependent anti-inflammatory effect in chicks. Comprehensive chromatographic analysis coupled with spectroscopic and X-ray study further allowed the assignment of one of the major anti-inflammatory constituents as a novel cassaine-type diterpene, erythroivorensin. The other major constituents were known anti-inflammatory compounds: a triterpene, betulinic acid and a flavonoid, eriodictyol. The dose (10-100mg/kg p.o.)-dependent anti-inflammatory effects of the three compounds were either comparable or more significant than the positive control, diclofenac.
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Authors | Francis A Armah, Kofi Annan, Abraham Y Mensah, Isaac K Amponsah, Derek A Tocher, Solomon Habtemariam |
Journal | Fitoterapia
(Fitoterapia)
Vol. 105
Pg. 37-42
(Sep 2015)
ISSN: 1873-6971 [Electronic] Netherlands |
PMID | 26057191
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Chemical References |
- Abietanes
- Anti-Inflammatory Agents
- Diterpenes
- Plant Extracts
- erythroivorensin
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Topics |
- Abietanes
(chemistry, isolation & purification)
- Animals
- Anti-Inflammatory Agents
(chemistry, isolation & purification)
- Chickens
- Diterpenes
(chemistry, isolation & purification)
- Fabaceae
(chemistry)
- Molecular Structure
- Plant Bark
(chemistry)
- Plant Extracts
(chemistry)
- Plant Roots
(chemistry)
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