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Relationship of HLA-DRB1 gene polymorphism with susceptibility to pulmonary tuberculosis: updated meta-analysis.

AbstractBACKGROUND:
Studies indicate that human leukocyte antigen (HLA) gene polymorphisms are implicated in the risk of pulmonary tuberculosis (PTB). However, research findings are contradictory.
OBJECTIVE:
To examine the association between HLA-DRB1 alleles and PTB risk using a meta-analysis on case-control studies.
METHODS:
We searched for relevant studies in the PubMed and EMBASE databases. We used fixed-effects or random-effects models and reported combined odds ratios (ORs) and 95% confidence intervals (CI). The Newcastle-Ottawa Scale (NOS) was used to estimate the quality of each case-control study.
RESULTS:
A total of 21 individual case-control studies were identified, including studies of 14 family alleles and 28 specific alleles. Compared with controls, DRB1*15 and DRB1*08:03 were found to have significantly higher frequencies in PTB patients; however, DRB1*03, DRB1*11, DRB1*11:03 and DRB1*12:02 had significantly lower frequencies in the total population. The association between other HLA-DRB1 family alleles and specific alleles and predisposition to PTB was not statistically significant. Among Asian populations, DRB1*03 and DRB1*07:01 were associated with a reduced incidence of PTB, while DRB1*15 and DRB1*08:03 were associated with an increased incidence of PTB.
CONCLUSION:
We conclude that HLA-DRB1 may be a valuable marker to predict the risk for PTB, especially in Asian populations.
AuthorsC-P Li, Y Zhou, X Xiang, Y Zhou, M He
JournalThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease (Int J Tuberc Lung Dis) Vol. 19 Issue 7 Pg. 841-9 (Jul 2015) ISSN: 1815-7920 [Electronic] France
PMID26056112 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Biomarkers
  • HLA-DRB1 Chains
Topics
  • Alleles
  • Asian People (genetics)
  • Biomarkers
  • Case-Control Studies
  • Gene Frequency
  • Genetic Predisposition to Disease
  • HLA-DRB1 Chains (genetics)
  • Humans
  • Odds Ratio
  • Polymorphism, Genetic
  • Tuberculosis, Pulmonary (genetics)

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