Abstract | BACKGROUND: OBJECTIVE: To examine the association between HLA-DRB1 alleles and PTB risk using a meta-analysis on case-control studies. METHODS: We searched for relevant studies in the PubMed and EMBASE databases. We used fixed-effects or random-effects models and reported combined odds ratios ( ORs) and 95% confidence intervals (CI). The Newcastle-Ottawa Scale (NOS) was used to estimate the quality of each case-control study. RESULTS: A total of 21 individual case-control studies were identified, including studies of 14 family alleles and 28 specific alleles. Compared with controls, DRB1*15 and DRB1*08:03 were found to have significantly higher frequencies in PTB patients; however, DRB1*03, DRB1*11, DRB1*11:03 and DRB1*12:02 had significantly lower frequencies in the total population. The association between other HLA-DRB1 family alleles and specific alleles and predisposition to PTB was not statistically significant. Among Asian populations, DRB1*03 and DRB1*07:01 were associated with a reduced incidence of PTB, while DRB1*15 and DRB1*08:03 were associated with an increased incidence of PTB. CONCLUSION: We conclude that HLA-DRB1 may be a valuable marker to predict the risk for PTB, especially in Asian populations.
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Authors | C-P Li, Y Zhou, X Xiang, Y Zhou, M He |
Journal | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
(Int J Tuberc Lung Dis)
Vol. 19
Issue 7
Pg. 841-9
(Jul 2015)
ISSN: 1815-7920 [Electronic] France |
PMID | 26056112
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Biomarkers
- HLA-DRB1 Chains
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Topics |
- Alleles
- Asian People
(genetics)
- Biomarkers
- Case-Control Studies
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-DRB1 Chains
(genetics)
- Humans
- Odds Ratio
- Polymorphism, Genetic
- Tuberculosis, Pulmonary
(genetics)
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