Abstract | BACKGROUND: Controversies remain over the safety and efficacy of vitamin E (i.e., α- tocopherol) supplementation use for the prevention of prostate cancer (CaP); however, associations of different tocopherol forms and CaP aggressiveness have yet to be examined. METHODS: This study examined whether food intake of tocopherols, vitamin E supplement use, and adipose tissue biomarkers of tocopherol were associated with CaP aggressiveness among African-American (AA, n = 1,023) and European-American (EA, n = 1,079) men diagnosed with incident CaP. Dietary tocopherols were estimated from a food frequency questionnaire, supplement use from questionnaire/inventory, and biomarkers from abdominal adipose samples measured using high-performance liquid chromatography. Odds ratios ( ORs) and 95% confidence intervals (95%CIs) were estimated from logistic regression comparing high-aggressive CaP to low/intermediate aggressive CaP, adjusting for covariates. RESULTS: Dietary intakes of α-and δ- tocopherol were related inversely to CaP aggressiveness among EAs [OR (95%CI), highest versus lowest quartile: α- tocopherol, 0.34 (0.17-0.69), P(trend) = 0.006; δ- tocopherol, 0.45 (0.21-0.95) P(trend) = 0.007]. Inverse associations between dietary and supplemental α- tocopherol and CaP aggressiveness were observed among AAs, though these did not reach statistical significance [OR (95%CI), highest versus lowest quartile: dietary α- tocopherol, 0.58 (0.28-1.19), P(trend) = 0.20; supplemental α- tocopherol, 0.64 (0.31-1.21) P(trend) = 0.15]. No significant association was observed between adipose tocopherol levels and CaP aggressiveness [OR (95%CI), highest versus lowest quartiles of α- tocopherol for EAs 1.43 (0.66-3.11) and AAs 0.66 (0.27-1.62)]. CONCLUSIONS: The inverse associations observed between dietary sources of tocopherols and CaP aggressiveness suggests a beneficial role of food sources of these tocopherols in CaP aggressiveness.
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Authors | Samuel O Antwi, Susan E Steck, L Joseph Su, James R Hébert, Hongmei Zhang, Elizabeth T H Fontham, Gary J Smith, Jeannette T Bensen, James L Mohler, Lenore Arab |
Journal | The Prostate
(Prostate)
Vol. 75
Issue 13
Pg. 1419-35
(Sep 2015)
ISSN: 1097-0045 [Electronic] United States |
PMID | 26053590
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 Wiley Periodicals, Inc. |
Chemical References |
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Topics |
- Adipose Tissue
(metabolism)
- Black or African American
- Aged
- Dietary Supplements
- Humans
- Louisiana
- Male
- Middle Aged
- Neoplasm Invasiveness
(pathology)
- North Carolina
- Prostatic Neoplasms
(metabolism, pathology, prevention & control)
- Tocopherols
(administration & dosage, metabolism)
- White People
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