Peroxide-based oxygen generating topical wound dressing for enhancing healing of dermal wounds.

Abstract

Oxygen generating biomaterials represent a new trend in regenerative medicine that aims to generate and supply oxygen at the site of requirement, to support tissue healing and regeneration. To enhance the healing of dermal wounds, we have developed a highly portable, in situ oxygen generating wound dressings that uses sodium percarbonate (SPO) and calcium peroxide (CPO) as chemical oxygen sources. The dressing continuously generated oxygen for more than 3 days, after which it was replaced. In the in vivo testing on porcine full-thickness porcine wound model, the SPO/CPO dressing showed enhanced wound healing during the 8 week study period. Quantitative measurements of wound healing related parameters, such as wound closure, reepithelialization, epidermal thickness and collagen content of dermis showed that supplying oxygen topically using the SPO/CPO dressing significantly accelerated the wound healing. An increase in neovascularization, as determined using Von Willebrand factor (vWF) and CD31 staining, was also observed in the presence of SPO/CPO dressing. This novel design for a wound dressing that contains oxygen generating biomaterials (SPO/CPO) for supplying topical oxygen, may find utility in treating various types of acute to chronic wounds.

• Authors: Prafulla K Chandra, Christina L Ross, Leona C Smith, Seon S Jeong, Jaehyun Kim, James J Yoo, Benjamin S Harrison
• Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (Wound Repair Regen) 2015 Nov-Dec Vol. 23 Issue 6 Pg. 830-41 ISSN: 1524-475X [Electronic] United States
• PMID: 26053405 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: © 2015 by the Wound Healing Society.

Chemical References

• Biocompatible Materials
• Peroxides
• calcium peroxide
• Oxygen

Topics

• Administration, Topical
• Animals
• Bandages
• Biocompatible Materials
• Disease Models, Animal
• Neovascularization, Physiologic
• Oxygen (pharmacology)
• Peroxides (pharmacology)
• Regeneration
• Regenerative Medicine
• Soft Tissue Injuries (pathology)
• Swine
• Wound Healing (drug effects)