Analgesic and anti-inflammatory effects of hydroalcoholic extract isolated from Semen vaccariae.

Abstract

Semen vaccariae, the seeds of Vaccaria segetalis (Neck.) Garcke, is usually used as an important medication for female mammary gland diseases; it has also been used to promote lactation for centuries in China. The purpose of this work was to evaluate the analgesic and anti-inflammatory effects of hydroalcoholic extract from semen vaccariae (HESV) with oral doses of 50, 100 and 200mg/kg•bw in mice and rats. We observed that the HESV could effectively inhibit acetic acid-induced abdominal contraction and could elevate the latency time to thermal stimuli in the hot-plate test in mice. In the xylene-induced ear-swelling test in mice, HESV could suppress the ear swelling. Additionally, HESV could significantly decrease the peritoneal capillary permeability and leukocyte infiltration in mice induced by the intraperitoneal injection of acetic acid. HESV also significantly reduced paw thickness 2-4 hours after the injection of carrageenan in the carrageenan-induced rat paw edema test. This study was the first to demonstrate that the oral administration of HESV might play an important role in the process of analgesia and anti-inflammation, supporting its use for female mammary gland diseases in traditional medicine.

• Authors: Lei Wang, Dongan Cui, Xurong Wang, Jingyan Zhang, Zhiqiang Yang, Zhe Qin, Dongan Cui, Xiaojun Kong, Xuezhi Wang, Jianxi Li
• Journal: Pakistan journal of pharmaceutical sciences (Pak J Pharm Sci) Vol. 28 Issue 3 Suppl Pg. 1043-8 (May 2015) ISSN: 1011-601X [Print] Pakistan
• PMID: 26051722 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alcohols
• Analgesics
• Anti-Inflammatory Agents
• Plant Extracts
• Solvents
• Xylenes
• Carrageenan
• Acetic Acid

Topics

• Acetic Acid
• Administration, Oral
• Alcohols (chemistry)
• Analgesics (administration & dosage, chemistry, isolation & purification, pharmacology)
• Animals
• Anti-Inflammatory Agents (administration & dosage, chemistry, isolation & purification, pharmacology)
• Capillary Permeability (drug effects)
• Carrageenan
• Chemotaxis, Leukocyte (drug effects)
• Disease Models, Animal
• Edema (chemically induced, immunology, metabolism, prevention & control)
• Hot Temperature
• Mice, Inbred BALB C
• Pain (etiology, physiopathology, prevention & control)
• Pain Threshold (drug effects)
• Phytotherapy
• Plant Extracts (administration & dosage, chemistry, isolation & purification, pharmacology)
• Plants, Medicinal
• Rats, Sprague-Dawley
• Reaction Time (drug effects)
• Seeds
• Solvents (chemistry)
• Time Factors
• Vaccaria (chemistry)
• Xylenes