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Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease.

Abstract
Cytotoxic molecules such as granulysin, perforin and granzymes produced by cytolytic T cells directly contribute to immune defense against tuberculosis (TB). In search for novel TB biomarkers, we have evaluated the levels of granzyme A in plasma obtained from QuantiFERON-TB Gold In tube (QFT-IT) assays from patients with active TB disease and subjects with latent TB infection (LTBI). Granzyme A serum levels in TB patients were significantly lower than values found in LTBI subjects even after subtraction of the unstimulated levels from the antigen-stimulated responses. The receiver operator characteristics (ROC) curve analysis comparing TB patients and LTBI groups, showed that at a cut-off value of granzyme A of <3.425pg/ml, the sensitivity and the specificity of the assay were 29.41% and 94.74%, respectively. Our results suggest that granzyme A could be considered another biomarker of TB, that can be used, other than IFN-γ, to discriminate between patients with active TB and LTBI subjects in a well characterized cohort of confirmed Mycobacterium tuberculosis-infected individuals.
AuthorsGiuliana Guggino, Valentina Orlando, Stella Cutrera, Marco P La Manna, Diana Di Liberto, Valentina Vanini, Elisa Petruccioli, Francesco Dieli, Delia Goletti, Nadia Caccamo
JournalImmunology letters (Immunol Lett) Vol. 166 Issue 2 Pg. 87-91 (Aug 2015) ISSN: 1879-0542 [Electronic] Netherlands
PMID26051682 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Antigens, Bacterial
  • Biomarkers
  • Interferon-gamma
  • Granzymes
Topics
  • Adult
  • Antigens, Bacterial (immunology)
  • Biomarkers
  • Case-Control Studies
  • Female
  • Granzymes (blood, metabolism)
  • Humans
  • Interferon-gamma (blood, metabolism)
  • Latent Tuberculosis (diagnosis, immunology, metabolism)
  • Male
  • Middle Aged
  • Mycobacterium tuberculosis (immunology)
  • ROC Curve
  • Tuberculosis (diagnosis, immunology, metabolism, microbiology, prevention & control)
  • Young Adult

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