A porphyrin photosensitized metal-organic framework for cancer cell apoptosis and caspase responsive theranostics.

Abstract	A photosensitized and caspase-responsive multifunctional nanoprobe was designed by assembling a porphyrin, a folate targeting-motif and a dye-labelled peptide in a metal-organic framework (MOF) cage, which significantly increases the singlet oxygen quantum yield of porphyrin by 6.2 times, and achieves high efficient cancer therapy and in situ therapeutic monitoring with caspase-3 activation. The integration of theranostic functions in a single nanocarrier holds great promise in precision cancer diagnosis and treatment.
Authors	Lei Zhang, Jianping Lei, Fengjiao Ma, Pinghua Ling, Jintong Liu, Huangxian Ju
Journal	Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 54 Pg. 10831-4 (Jul 11 2015) ISSN: 1364-548X [Electronic] England
PMID	26051476 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Drug Carriers Organometallic Compounds Photosensitizing Agents Porphyrins Singlet Oxygen Caspase 3
Topics	Apoptosis (drug effects) Caspase 3 (metabolism) Cell Line, Tumor Drug Carriers (chemistry) HeLa Cells Humans Microscopy, Confocal Organometallic Compounds (chemistry) Photosensitizing Agents (chemistry, toxicity) Porphyrins (chemistry, toxicity) Singlet Oxygen (metabolism) Theranostic Nanomedicine

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