Abstract | BACKGROUND: Overconsumption of alcohol has significant negative effects on an individual's health and contributes to an enormous economic impact on society as a whole. Pharmacotherapies to curb excessive drinking are important for treating alcohol use disorders. METHODS: Twenty (20) men participated in a placebo-controlled, double-blind, between subjects design experiment (n=10/group) that tested the effects of kudzu extract (Alkontrol-Herbal™) for its ability to alter alcohol consumption in a natural settings laboratory. A single dose of kudzu extract (2g total with an active isoflavone content of 520mg) or placebo was administered 2.5h before the onset of a 90min afternoon drinking session during which participants had the opportunity to drink up to 6 beers ad libitum; water and juice were always available as alternative beverages. RESULTS: During the baseline session, the placebo-randomized group consumed 2.7±0.78 beers before treatment and increased consumption to 3.4±1.1 beers after treatment. The kudzu group significantly reduced consumption from 3.0±1.7 at baseline to 1.9±1.3 beers after treatment. The placebo-treated group opened 33 beers during baseline conditions and 38 following treatment whereas the kudzu-treated group opened 32 beers during baseline conditions and only 21 following treatment. Additionally, kudzu-treated participants drank slower. CONCLUSION: This is the first demonstration that a single dose of kudzu extract quickly reduces alcohol consumption in a binge drinking paradigm. These data add to the mounting clinical evidence that kudzu extract may be a safe and effective adjunctive pharmacotherapy for alcohol abuse and dependence.
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Authors | David M Penetar, Lindsay H Toto, David Y-W Lee, Scott E Lukas |
Journal | Drug and alcohol dependence
(Drug Alcohol Depend)
Vol. 153
Pg. 194-200
(Aug 01 2015)
ISSN: 1879-0046 [Electronic] Ireland |
PMID | 26048637
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Isoflavones
- Plant Extracts
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Topics |
- Adult
- Alcohol Drinking
(drug therapy)
- Beer
- Binge Drinking
(drug therapy)
- Double-Blind Method
- Humans
- Isoflavones
(therapeutic use)
- Male
- Phytotherapy
- Plant Extracts
(administration & dosage)
- Pueraria
(chemistry)
- Young Adult
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