Recent approaches for reducing hemolytic activity of chemotherapeutic agents.

Abstract

Drug induced hemolysis is a frequent complication associated with chemotherapy. It results from interaction of drug with erythrocyte membrane and leads to cell lysis. In recent past, various approaches were made to reduce drug-induced hemolysis, which includes drug polymer conjugation, drug delivery via colloidal carriers and hydrogels, co-administration of botanical agents and modification in molecular chemistry of drug molecules. The basic concept behind these strategies is to protect the red blood cells from membrane damaging effects of drugs. There are several examples of drug polymer conjugate that either are approved by Food and Drug Administration or are under clinical trial for delivering drugs with reduced toxicities. Likewise, colloidal carriers are also used successfully nowadays for the delivery of various chemotherapeutic agents like gemcitabine and amphotericin B with remarkable decrease in their hemolytic activity. Similarly, co-administration of botanical agents with drugs works as secondary system proving protection and strength to erythrocyte membranes. In addition to the above statement, interaction hindrance between RBC and drug molecule by molecular modification plays an important role in reducing hemolysis. This review predominantly describes the above recent approaches explored to achieve the reduced hemolytic activity of drugs especially chemotherapeutic agents.

• Authors: Gunjan Jeswani, Amit Alexander, Shailendra Saraf, Swarnlata Saraf, Azra Qureshi, Ajazuddin
• Journal: Journal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 211 Pg. 10-21 (Aug 10 2015) ISSN: 1873-4995 [Electronic] Netherlands
• PMID: 26047758 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents
• Drug Carriers

Topics

• Animals
• Antineoplastic Agents (administration & dosage, adverse effects, metabolism)
• Clinical Trials as Topic (methods)
• Dose-Response Relationship, Drug
• Drug Carriers (administration & dosage, adverse effects, metabolism)
• Erythrocyte Membrane (drug effects, metabolism)
• Hemolysis (drug effects, physiology)
• Humans