miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas.

Abstract

The aim of this study was to compare the clinicopathological significance of miR-200a/miR-141 and miR-205 expression in endometrioid carcinomas (ECs) versus nonendometrioid carcinomas (NECs) and to assess their correlation with hormone receptor status. miR-200a/miR-141 and miR-205 expression in 154 endometrial cancers was determined by qRT-PCR. The status of estrogen and progesterone receptor (ER/PR) was assessed using immunohistochemistry. miR-200a/miR-141 and miR-205 increased significantly in ECs and in NECs. The expression level of miR-200a was significantly higher in NECs than in ECs (P=0.025). Furthermore, there was a trend that NECs with worse clinicopathological variables had a higher miR-200a expression, while an inverse trend existed in ECs. miR-205 upregulation occurred frequently in NECs without lymph node metastases (P=0.030), whereas such association was not present in ECs. Interestingly, In ECs, miR-200a/miR-141 upregulation occurred frequently in the hormone receptor positive subgroups than the negative subgroups (P<0.05). Similarly, the expression level of miR-205 was higher in the hormone receptor positive subgroups and the association between miR-205 and PR reached statistical significance (P=0.024). In contrast, in NECs, a negative correlation was found between miR-200a/miR-141 and ER or PR status. Meanwhile, in ECs, miR-200a upregulation correlated with prolonged survival in the ER positive subgroup (P=0.046), whereas an inverse trend existed in the ER negative subgroup. Our findings suggest that miR-200a/miR-141 and miR-205 increased significantly in ECs and in NECs. However, they might behave differently in ECs versus NECs. miR-200a/miR-141 and miR-205 might be associated with hormone receptor status in endometrial cancer and may possess prognostic impacts.

• Authors: Ying Dong, Jing-Wen Si, Wen-Ting Li, Li Liang, Jian Zhao, Mei Zhou, Dong Li, Ting Li
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 8 Issue 3 Pg. 2864-75 ( 2015) ISSN: 1936-2625 [Electronic] United States
• PMID: 26045795 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• MIRN141 microRNA, human
• MIRN200 microRNA, human
• MIRN205 microRNA, human
• MicroRNAs
• Receptors, Estrogen
• Receptors, Progesterone

Topics

• Adult
• Aged
• Carcinoma (genetics, mortality)
• Endometrial Neoplasms (genetics, mortality)
• Female
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• MicroRNAs (biosynthesis)
• Middle Aged
• Prognosis
• Proportional Hazards Models
• Real-Time Polymerase Chain Reaction
• Receptors, Estrogen (biosynthesis, genetics)
• Receptors, Progesterone (biosynthesis, genetics)
• Up-Regulation