T-wave oversensing in patients with Brugada syndrome: true bipolar versus integrated bipolar implantable cardioverter defibrillator leads: multicenter retrospective study.

Abstract

BACKGROUND:

It is thought that dedicated bipolar are more susceptible to T-wave oversensing when compared with integrated bipolar leads. This could be of extreme importance in patients with Brugada syndrome (BrS) because T-wave oversensing in this population is more frequent when compared with other implantable cardioverter defibrillator (ICD) recipients without BrS. We aimed to compare the incidence of T-wave oversensing in patients with BrS according to the type of lead (integrated bipolar versus true/dedicated bipolar).

METHODS AND RESULTS:

All patients diagnosed with BrS with an ICD implant in 10 tertiary hospitals between 1993 and 2013 were included in the study. A total of 480 patients were included (mean age, 45.6±14 years). During a mean follow-up of 74.9±51.7 months (median, 69; range, 2-236), 28 patients had T-wave oversensing (5.8%), leading to inappropriate shock in 18 (3.8%). All these events occurred in patients with true bipolar ICD leads (P=0.01) and in 2 patients it was solved instantaneously by changing the configuration from a dedicated to an integrated bipolar sensing configuration. In the stepwise multivariate models, only integrated bipolar ICD leads (hazard ratio, 0.34; 95% confidence interval, 0.171-0.675; P=0.002) was independent predictor of non-T-wave oversensing.

CONCLUSIONS:

T-wave oversensing is a potential reason of inappropriate shocks in patients with BrS receiving ICDs. In the vast majority it can be solved by reprogramming. However, in some patients it still requires invasive intervention. Importantly, incidence is significantly lower using an integrated bipolar lead system when compared with a dedicated bipolar lead system and hence the latter should be routinely used in BrS cases.

• Authors: Moisés Rodríguez-Mañero, Carlo de Asmundis, Frédéric Sacher, Elena Arbelo, Vincent Probst, Jesús Castro-Hevia, Philippe Maury, Anne Rollin, Pier Lambiase, Ignacio García-Bolao, Gian-Battista Chierchia, Kengo Fukushima Kusano, Jean-Baptiste Gourraud, Richard Schilling, Tsukasa Kamakura, Jose Luis Martínez-Sande, Michel Haïssaguerre, José Ramón González-Juanatey, Jose Brugada, Pedro Brugada
• Journal: Circulation. Arrhythmia and electrophysiology (Circ Arrhythm Electrophysiol) Vol. 8 Issue 4 Pg. 792-8 (Aug 2015) ISSN: 1941-3084 [Electronic] United States
• PMID: 26041387 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 American Heart Association, Inc.

Topics

• Brugada Syndrome (physiopathology, therapy)
• Defibrillators, Implantable
• Electrocardiography
• Equipment Design
• Female
• Follow-Up Studies
• Heart Rate (physiology)
• Humans
• Male
• Middle Aged
• Retrospective Studies