Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2.

Abstract

Linalool, a natural compound of the essential oils, has been reported to have anti-inflammatory effects. This study aimed to investigate the anti-inflammatory effects and mechanism of linalool in LPS-stimulated BV2 microglia cells. BV2 microglia cells were stimulated with LPS in the presence or absence of linalool. The production of inflammatory mediators TNF-α, IL-1β, NO, and PGE2 as well as Nrf2, HO-1 expression were detected. Our results showed that linalool inhibited LPS-induced TNF-α, IL-1β, NO, and PGE2 production in a dose-dependent manner. Linalool also inhibited LPS-induced NF-κB activation. Treatment of linalool induced nuclear translocation of Nrf2 and expression of HO-1. In addition, our results showed that the anti-inflammatory effect of linalool was attenuated by transfection with Nrf2 siRNA. In conclusion, these results suggested that linalool inhibits LPS-induced inflammation in BV2 microglia cells by activating Nrf2/HO-1 signaling pathway.

• Authors: Yang Li, Ou Lv, Fenggang Zhou, Qingsong Li, Zhichao Wu, Yongri Zheng
• Journal: Neurochemical research (Neurochem Res) Vol. 40 Issue 7 Pg. 1520-5 (Jul 2015) ISSN: 1573-6903 [Electronic] United States
• PMID: 26040565 (Publication Type: Journal Article)

Chemical References

• Acyclic Monoterpenes
• Inflammation Mediators
• Lipopolysaccharides
• Monoterpenes
• NF-kappa B
• linalool
• Heme Oxygenase-1
• Dinoprostone

Topics

• Acyclic Monoterpenes
• Animals
• Dinoprostone (biosynthesis)
• Heme Oxygenase-1 (metabolism)
• Inflammation (chemically induced, prevention & control)
• Inflammation Mediators (metabolism)
• Lipopolysaccharides (toxicity)
• Mice
• Microglia (cytology, drug effects, metabolism)
• Monoterpenes (pharmacology)
• NF-kappa B (metabolism)
• Up-Regulation (drug effects)