Abstract |
Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor with a low-grade malignancy, and EMC with high-grade histopathological features is exceedingly rare. Furthermore, EMC with intracellular mucin is also extremely rare. We report an uncommon case of a high-grade EMC of the parotid gland with mucous cell differentiation in a 66-year old Japanese woman who noticed a right palpable parotid mass increasing in size within a one-year period. The cytological specimen showed a focally biphasic structure and included isolated or discohesive piled-up clusters with hyaline globules surrounded by neoplastic cells with nuclear atypia. The gross examination revealed a relatively well-demarcated, multinodular gray-whitish and solid mass. Histologically, the tumor consisted of variably sized solid nests or trabeculae with central necrosis and increased mitotic activity, and invaded into adjacent skeletal muscles. Immunohistochemically, the biphasic ductal and myoepithelial differentiation of this tumor confirmed the diagnosis of high-grade EMC. Furthermore, numerous small nests with d-PAS and alcian blue-positive mucous cells predominated in about 5% of the whole tumor, and these mucous cells were encompassed by neoplastic myoepithelial cells. We should recognize this variant of EMC because we can't rule out the possibility of EMC even in the presence of mucous cells.
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Authors | Kazuhiro Sentani, Ikuko Ogawa, Naohiro Uraoka, Masayuki Ikeda, Naoki Hayashi, Takuya Hattori, Yui Hattori, Naohide Oue, Takashi Takata, Wataru Yasui |
Journal | Pathology international
(Pathol Int)
Vol. 65
Issue 9
Pg. 490-4
(Sep 2015)
ISSN: 1440-1827 [Electronic] Australia |
PMID | 26037059
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2015 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd. |
Topics |
- Aged
- Biopsy, Fine-Needle
- Cell Differentiation
- Female
- Goblet Cells
(pathology)
- Humans
- Myoepithelioma
(pathology, surgery)
- Neoplasms, Glandular and Epithelial
(pathology, surgery)
- Parotid Gland
(pathology, surgery)
- Parotid Neoplasms
(pathology, surgery)
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