The matrikine PGP as a potential biomarker in COPD.

The lack of a well-characterized biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD) has increased interest toward finding one, because this would provide potential insight into disease pathogenesis and progression. Since persistent neutrophilia is an important hallmark in COPD Pro-Gly-Pro (PGP), an extracellular matrix-derived neutrophil chemoattractant, has been suggested to be a potential biomarker in COPD. The purpose of this review is to critically examine both biological and clinical data related to the role of PGP in COPD, with particular focus on its role as a clinical biomarker and potential therapeutic target in disease. The data provided in this review will offer insight into the potential use of PGP as end point for future clinical studies in COPD lung disease. Following PGP levels during disease might serve as a guide for the progression of lung disorders.
AuthorsMojtaba Abdul Roda, Amanda M Fernstrand, Frank A Redegeld, J Edwin Blalock, Amit Gaggar, Gert Folkerts
JournalAmerican journal of physiology. Lung cellular and molecular physiology (Am J Physiol Lung Cell Mol Physiol) Vol. 308 Issue 11 Pg. L1095-101 (Jun 1 2015) ISSN: 1522-1504 [Electronic] United States
PMID26033353 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2015 the American Physiological Society.
Chemical References
  • Biomarkers
  • Chemokines
  • Leukotriene A4
  • Oligopeptides
  • prolyl-glycyl-proline
  • Proline
  • Animals
  • Biomarkers (metabolism)
  • Chemokines (metabolism)
  • Extracellular Matrix (metabolism)
  • Humans
  • Leukotriene A4 (metabolism)
  • Neutrophils (immunology)
  • Oligopeptides (metabolism)
  • Proline (analogs & derivatives, metabolism)
  • Pulmonary Disease, Chronic Obstructive (diagnosis, metabolism)

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