A novel approach to the management of a central giant cell granuloma with denosumab: A case report and review of current treatments.

Abstract

PURPOSE:

To describe the efficacy of denosumab in the treatment of an aggressive giant cell granuloma of the mandible.

METHODS:

Denosumab was administered to a patient with a large aggressive giant cell granuloma of the mandible resistant to standard medical therapy. The effectiveness and response was measured on the basis of patient symptoms and radiological parameters.

RESULTS:

A significant reduction in patient symptoms was reported in association with tumour regression on follow up radiographs.

CONCLUSION:

This report demonstrates potential use of denosumab in aggressive giant cell granulomas of the jaws that have been resistant to medical therapy.

• Authors: Benjamin Gupta, Norman Stanton, Hedley Coleman, Chris White, Jasvir Singh
• Journal: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery (J Craniomaxillofac Surg) Vol. 43 Issue 7 Pg. 1127-32 (Sep 2015) ISSN: 1878-4119 [Electronic] Scotland
• PMID: 26032758 (Publication Type: Case Reports, Journal Article)
• Copyright: Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Bone Density Conservation Agents
• Denosumab

Topics

• Adult
• Bone Density Conservation Agents (administration & dosage, therapeutic use)
• Denosumab (administration & dosage, therapeutic use)
• Female
• Granuloma, Giant Cell (drug therapy)
• Humans