Analgesic effect of nasal salmon calcitonin during the early post-fracture period of the distal radius fracture.

Abstract

OBJECTIVES:

To investigate the analgesic effect of nasal salmon calcitonin on the post-fracture period of distal radius fracture.

METHODS:

In this prospective randomized double-blind study, forty-one postmenopausal women with a recent distal radius fracture treated conservatively were randomly assigned to receive either 200 IU of intranasal salmon calcitonin or placebo daily for 3 months following fracture. The assessment of the patient's pain was recorded using the Visual Analogue Scale (VAS).

RESULTS:

The average age of the calcitonin group was 67.11 (SD, ±8.68) years and 64.91 (SD, ±7.48) of the placebo group. In the calcitonin group, the mean VAS score improved from 4.05 to 0.53 while in the placebo group from 3.36 to 0.32. A higher decrease of VAS score during the first post-fracture period was observed in the calcitonin group.

CONCLUSIONS:

In the study, there is a statistically significant calcitonin mediated analgesic effect in the immediate post fracture period (at 10 days) when compared to placebo group. These results are in accordance with literature referring to the analgesic effect of calcitonin in the acute osteoporotic vertebral compression fracture. Thus calcitonin administration could be recommended to a short term course in acute osteoporotic conservatively treated distal radius fractures.

• Authors: A Karponis, Stavroula Rizou, D Pallis, C P Zafeiris, D F Georgiou, A Galanos, F Giannoulis, G P Lyritis
• Journal: Journal of musculoskeletal & neuronal interactions (J Musculoskelet Neuronal Interact) Vol. 15 Issue 2 Pg. 186-9 (06 2015) ISSN: 1108-7161 [Print] Greece
• PMID: 26032211 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• salmon calcitonin
• Calcitonin

Topics

• Administration, Intranasal
• Aged
• Analgesics (administration & dosage, therapeutic use)
• Calcitonin (administration & dosage, therapeutic use)
• Double-Blind Method
• Female
• Humans
• Middle Aged
• Osteoporosis (complications)
• Osteoporosis, Postmenopausal (complications, drug therapy)
• Osteoporotic Fractures (complications, drug therapy)
• Pain (drug therapy, etiology)
• Pain Measurement
• Prospective Studies
• Radius Fractures (complications, drug therapy)
• Treatment Outcome