Synergy between cannabidiol, cannabidiolic acid, and Δ⁹-tetrahydrocannabinol in the regulation of emesis in the Suncus murinus (house musk shrew).

Abstract

Smoked marijuana contains over 100 different cannabinoids, including the psychoactive compound Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC, CBD, and its acidic precursor, cannabidiolic acid (CBDA), have all been shown to have antiemetic properties in the Suncus murinus (S. murinus; house musk shrew). Here we show that when subthreshold antiemetic doses of CBD (2.5 mg/kg ip) or CBDA (0.05 mg/kg ip) are combined with a subthreshold antiemetic dose of THC (1 mg/kg ip) in the S. murinus, both lithium-chloride-induced vomiting and abdominal retching are dramatically suppressed. These results suggest that combined effects of these compounds may lead to better control of vomiting with fewer side effects.

• Authors: Erin M Rock, Linda A Parker
• Journal: Behavioral neuroscience (Behav Neurosci) Vol. 129 Issue 3 Pg. 368-70 (Jun 2015) ISSN: 1939-0084 [Electronic] United States
• PMID: 26030435 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2015 APA, all rights reserved).

Chemical References

• Antiemetics
• Cannabinoids
• Cannabidiol
• Dronabinol
• cannabidiolic acid
• Lithium Chloride

Topics

• Animals
• Antiemetics (pharmacology)
• Cannabidiol (pharmacology)
• Cannabinoids (pharmacology)
• Disease Models, Animal
• Dronabinol (pharmacology)
• Drug Therapy, Combination
• Female
• Lithium Chloride
• Male
• Shrews
• Vomiting (drug therapy)