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Serum procollagen III peptide in alcoholic and other chronic liver diseases.

Abstract
Increased levels of serum procollagen III peptide (P-III-P) have been found in patients with alcoholic hepatitis and cirrhosis. Serum P-III-P was increased (greater than 15 micrograms/l) in 38 of 44 (86%) patients with alcoholic liver cirrhosis, in 6 of 20 (30%) with fatty liver, in 1 of 13 (8%) with non-alcoholic fatty liver, and in 3 of 14 (21%) with other chronic liver diseases. Median serum P-III-P was almost three times higher in alcoholic liver cirrhosis than in alcoholic fatty liver (p less than 0.001). Serum P-III-P was increased in three of six patients with alcoholic fatty liver and periportal fibrosis. In the total material (n = 91), a statistically significant negative correlation between serum P-III-P and albumin (r = -0.71, p less than 0.001) and Normotest (r = -0.63, p less than 0.001), respectively, and a positive correlation between serum P-III-P and bilirubin (r = 0.65, p less than 0.001) were found. The serum level of P-III-P had no prognostic value concerning the mortality in patients with alcoholic cirrhosis.
AuthorsH Bell, N Raknerud, H Orjasaeter, E Haug
JournalScandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 24 Issue 10 Pg. 1217-22 (Dec 1989) ISSN: 0036-5521 [Print] England
PMID2602904 (Publication Type: Journal Article)
Chemical References
  • Immunoglobulins
  • Serum Albumin
  • Bilirubin
Topics
  • Adult
  • Aged
  • Bilirubin (blood)
  • Fatty Liver (blood, metabolism)
  • Fatty Liver, Alcoholic (blood, metabolism)
  • Female
  • Hepatitis, Alcoholic (blood, metabolism)
  • Humans
  • Immunoglobulins (analysis)
  • Liver Cirrhosis, Alcoholic (blood, metabolism)
  • Liver Diseases (blood, metabolism)
  • Liver Neoplasms (blood, metabolism)
  • Male
  • Middle Aged
  • Serum Albumin (analysis)

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