The aim and objective of the present investigation was to evaluate the antiarthritic and
antioxidant effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside (UFD) in chemically induced arthritic rats. The different doses of the UFD were tested against the
turpentine oil (TO),
formaldehyde induced acute
arthritis and complete fruend's adjuvant (CFA) induced chronic
arthritis in Wistar rats. Arthritic assessment and
body weight was measured at regular interval till 28 days. On day 28, all the groups animals were anaesthetized, blood were collected from the puncturing the ratro orbital and estimated the hematological parameters. The animals were sacrificed; synovial tissue was extracted and estimated the
malonaldehyde (MDA),
glutathione (GSH),
glutathione peroxidase (GPx) and
superoxide dismutase (SOD). The different doses of the UFD showed the protective effect against
turpentine oil,
formaldehyde induced acute
arthritis and CFA induced chronic
arthritis at dose dependent manner. Acute model of
arthritis such as TOand
formaldehyde induced
inflammation due to releasing of the inflammatory mediators; significantly inhibited by the UFD at dose dependent manner. CFA induced arthritic rats treated with the different doses of the UFD showed the inhibitory effect on the delayed increase in joint diameter as seen in arthritic control group rats. UFD significantly improved the arthritic index,
body weight and confirmed the antiarthritic effect. UFD showed the effect on the hematological parameter such as improved the level of the RBC, Hb and decline the level of the EBC, ESR and confirmed the immune suppressive effect. UFD significantly improved the level of the
endogenous antioxidant and confirmed the
antioxidant effect. This present investigation suggests that the UFD has prominent antiarthritic impact which can be endorsed to its antiarthritic and
antioxidant effects.